Liga 1 - Sezon Regular - Meciurile Etapei 18
| Dec 3, 2021 21:00 | ACS FC Academica Clinceni | 1 - 0 | SC Dinamo 1948 SA |  |
| Dec 4, 2021 15:00 | AFC Chindia Târgovişte | 0 - 1 | FC CFR 1907 Cluj SA | |
| Dec 4, 2021 21:30 | Farul Constanţa | 2 - 0 | Fotbal Club Rapid 1923 SA | |
| Dec 5, 2021 13:30 | CS Mioveni | 0 - 2 | ACS Sepsi OSK Sfântu Gheorghe | |
| Dec 5, 2021 16:00 | U Craiova 1948 SA | 0 - 2 | SC FC Voluntari SA | |
| Dec 5, 2021 21:30 | SC Fotbal Club FCSB SA | 2 - 1 | AFC UTA Arad | |
| Dec 6, 2021 17:30 | ACS Campionii Fotbal Club Argeş | 1 - 2 | CS Gaz Metan Mediaş | |
| Dec 6, 2021 20:30 | AFC Botoşani | 2 - 2 | Universitatea Craiova | |
| Loc | Echipa | M | V | E | I | Gol | +/- | Pct |
| 1. | FC CFR 1907 Cluj SA | 18 | 16 | 0 | 2 | 28-8 | 20 | 48 |
| 2. | SC Fotbal Club FCSB SA | 18 | 12 | 4 | 2 | 34-16 | 18 | 40 |
| 3. | SC FC Voluntari SA | 18 | 10 | 2 | 6 | 22-18 | 4 | 32 |
| 4. | Universitatea Craiova | 18 | 9 | 2 | 7 | 34-21 | 13 | 29 |
| 5. | Farul Constanţa | 18 | 8 | 5 | 5 | 21-10 | 11 | 29 |
| 6. | AFC Botoşani | 18 | 7 | 8 | 3 | 18-17 | 1 | 29 |
| 7. | Fotbal Club Rapid 1923 SA | 18 | 7 | 7 | 4 | 22-17 | 5 | 28 |
| 8. | ACS Campionii Fotbal Club Argeş | 18 | 8 | 3 | 7 | 18-14 | 4 | 27 |
| 9. | AFC UTA Arad | 18 | 6 | 7 | 5 | 16-13 | 3 | 25 |
| 10. | ACS Sepsi OSK Sfântu Gheorghe | 18 | 4 | 9 | 5 | 19-17 | 2 | 21 |
| 11. | AFC Chindia Târgovişte | 18 | 4 | 7 | 7 | 12-13 | -1 | 19 |
| 12. | CS Gaz Metan Mediaş | 18 | 5 | 4 | 9 | 15-21 | -6 | 19 |
| 13. | CS Mioveni | 18 | 4 | 5 | 9 | 11-25 | -14 | 17 |
| 14. | U Craiova 1948 SA | 18 | 3 | 6 | 9 | 11-19 | -8 | 15 |
| 15. | SC Dinamo 1948 SA | 18 | 2 | 3 | 13 | 13-39 | -26 | 9 |
| 16. | ACS FC Academica Clinceni | 18 | 1 | 4 | 13 | 13-39 | -26 | 7 |