Liga 2 - Meciurile Etapei 1
| Dec 3, 2021 17:00 | CS Concordia Chiajna | 0 - 0 | AFC Hermannstadt |  |
| Dec 4, 2021 11:00 | AFC Dunărea 2005 Călăraşi | 3 - 1 | AFC 1919 Dacia Unirea Brăila | |
| Dec 4, 2021 11:00 | AFC Unirea 04 Slobozia | 2 - 0 | ACS Viitorul Pandurii Târgu Jiu | |
| Dec 4, 2021 11:00 | Clubul Sportiv Comunal 1599 Şelimbăr | 0 - 0 | ACSM Politehnica Iaşi | |
| Dec 4, 2021 11:00 | Fotbal Club Braşov | 4 - 2 | AFC Unirea Constanţa | |
| Dec 4, 2021 12:00 | FC Unirea Dej | 1 - 0 | FC Metaloglobus Bucureşti | |
| Dec 4, 2021 12:00 | AFC Astra | 0 - 2 | Politehnica Timișoara | |
| Dec 4, 2021 12:30 | Clubul Sportiv al Armatei Steaua | 1 - 0 | AS Fotbal Club Buzău | |
| Dec 6, 2021 15:30 | SC Fotbal Club Ripensia Timișoara | - | AFK Csikszereda Miercurea Ciuc | |
| Dec 7, 2021 17:00 | ACS Petrolul 52 | - | AS FC Universitatea Cluj | |
* Clubul AFC Astra a fost sancţionat cu o penalitate de 14 puncte prin deciziile CDE din 16.06.2021, 30.06.2021, 07.07.2021, 14.07.2021, 25.08.2021, 22.09.2021 şi 22.09.2021
| Loc | Echipa | M | V | E | I | Gol | +/- | Pct |
| 1. | ACS Petrolul 52 | 15 | 13 | 0 | 2 | 34-5 | 29 | 39 |
| 2. | AFC Hermannstadt | 16 | 10 | 5 | 1 | 33-12 | 21 | 35 |
| 3. | AS FC Universitatea Cluj | 15 | 11 | 0 | 4 | 25-13 | 12 | 33 |
| 4. | CS Concordia Chiajna | 16 | 9 | 5 | 2 | 17-6 | 11 | 32 |
| 5. | AS Fotbal Club Buzău | 16 | 8 | 4 | 4 | 39-12 | 27 | 28 |
| 6. | Clubul Sportiv al Armatei Steaua | 16 | 8 | 4 | 4 | 20-11 | 9 | 28 |
| 7. | AFC Unirea 04 Slobozia | 16 | 6 | 6 | 4 | 21-13 | 8 | 24 |
| 8. | AFK Csikszereda Miercurea Ciuc | 15 | 7 | 2 | 6 | 24-21 | 3 | 23 |
| 9. | Clubul Sportiv Comunal 1599 Şelimbăr | 16 | 6 | 5 | 5 | 18-21 | -3 | 23 |
| 10. | FC Unirea Dej | 16 | 6 | 4 | 6 | 15-14 | 1 | 22 |
| 11. | FC Metaloglobus Bucureşti | 16 | 6 | 4 | 6 | 18-20 | -2 | 22 |
| 12. | ACSM Politehnica Iaşi | 16 | 6 | 3 | 7 | 20-16 | 4 | 21 |
| 13. | SC Fotbal Club Ripensia Timișoara | 15 | 5 | 6 | 4 | 16-16 | 0 | 21 |
| 14. | Politehnica Timișoara | 16 | 6 | 2 | 8 | 18-22 | -4 | 20 |
| 15. | ACS Viitorul Pandurii Târgu Jiu | 16 | 5 | 5 | 6 | 15-19 | -4 | 20 |
| 16. | Fotbal Club Braşov | 16 | 3 | 3 | 10 | 14-28 | -14 | 12 |
| 17. | AFC Unirea Constanţa | 16 | 2 | 2 | 12 | 13-44 | -31 | 8 |
| 18. | AFC Dunărea 2005 Călăraşi | 16 | 1 | 4 | 11 | 12-33 | -21 | 7 |
| 19. | AFC Astra | 16 | 5 | 4 | 7 | 17-22 | -5 | 5 |
| 20. | AFC 1919 Dacia Unirea Brăila | 16 | 0 | 2 | 14 | 7-48 | -41 | 2 |