Liga 2 - Meciurile Etapei 4
| Aug 19, 2021 18:00 | FC Metaloglobus Bucureşti | 1 - 1 | AFC Hermannstadt |  |
| Aug 21, 2021 11:00 | AFC Dunărea 2005 Călăraşi | 0 - 3 | AS Fotbal Club Buzău | |
| Aug 21, 2021 11:00 | AFC Unirea Constanţa | 0 - 2 | Politehnica Timișoara | |
| Aug 21, 2021 11:00 | AFC 1919 Dacia Unirea Brăila | 1 - 1 | AFC Astra | |
| Aug 21, 2021 11:00 | SC Fotbal Club Ripensia Timișoara | 1 - 1 | Fotbal Club Braşov | |
| Aug 21, 2021 11:00 | FC Unirea Dej | 3 - 0 | CSC 1599 Şelimbăr | |
| Aug 21, 2021 16:00 | ACSM Politehnica Iaşi | 2 - 0 | AS FC Universitatea Cluj | |
| Aug 22, 2021 12:00 | ACS Viitorul Pandurii Târgu Jiu | 0 - 3 | ACS Petrolul 52 | |
| Aug 22, 2021 16:30 | AFC Unirea 04 Slobozia | 1 - 1 | Clubul Sportiv al Armatei Steaua | |
| Aug 23, 2021 16:30 | AFK Csikszereda Miercurea Ciuc | 0 - 3 | CS Concordia Chiajna | |
* Clubul AFC Astra a fost sancţionat cu o penalitate de 20 puncte prin deciziile CDE din 16.06.2021, 30.06.2021, 07.07.2021, 14.07.2021, 25.08.2021, 22.09.2021, 22.09.2021 şi 28.01.2022
| Loc | Echipa | M | V | E | I | Gol | +/- | Pct |
| 1. | CS Concordia Chiajna | 4 | 4 | 0 | 0 | 8-1 | 7 | 12 |
| 2. | AFC Unirea 04 Slobozia | 4 | 3 | 1 | 0 | 11-1 | 10 | 10 |
| 3. | Clubul Sportiv al Armatei Steaua | 4 | 3 | 1 | 0 | 9-3 | 6 | 10 |
| 4. | AFC Hermannstadt | 4 | 3 | 1 | 0 | 7-3 | 4 | 10 |
| 5. | ACS Petrolul 52 | 4 | 3 | 0 | 1 | 7-1 | 6 | 9 |
| 6. | AS FC Universitatea Cluj | 4 | 3 | 0 | 1 | 5-2 | 3 | 9 |
| 7. | Politehnica Timișoara | 4 | 2 | 1 | 1 | 6-5 | 1 | 7 |
| 8. | FC Metaloglobus Bucureşti | 4 | 2 | 1 | 1 | 5-4 | 1 | 7 |
| 9. | SC Fotbal Club Ripensia Timișoara | 4 | 1 | 3 | 0 | 6-4 | 2 | 6 |
| 10. | FC Unirea Dej | 4 | 1 | 2 | 1 | 3-2 | 1 | 5 |
| 11. | AS Fotbal Club Buzău | 4 | 1 | 1 | 2 | 5-4 | 1 | 4 |
| 12. | ACSM Politehnica Iaşi | 4 | 1 | 0 | 3 | 3-5 | -2 | 3 |
| 13. | CSC 1599 Şelimbăr | 4 | 1 | 0 | 3 | 3-8 | -5 | 3 |
| 14. | Fotbal Club Braşov | 4 | 0 | 3 | 1 | 3-9 | -6 | 3 |
| 15. | AFC Dunărea 2005 Călăraşi | 4 | 0 | 2 | 2 | 4-9 | -5 | 2 |
| 16. | AFC 1919 Dacia Unirea Brăila | 4 | 0 | 2 | 2 | 4-9 | -5 | 2 |
| 17. | ACS Viitorul Pandurii Târgu Jiu | 4 | 0 | 1 | 3 | 2-8 | -6 | 1 |
| 18. | AFC Unirea Constanţa | 4 | 0 | 0 | 4 | 0-7 | -7 | 0 |
| 19. | AFK Csikszereda Miercurea Ciuc | 4 | 0 | 0 | 4 | 0-7 | -7 | 0 |
| 20. | AFC Astra | 4 | 2 | 1 | 1 | 4-3 | 1 | -13 |